于晨课题组 
基因组工程 | 基因治疗

PAPERS
SZBL

Sex differences orchestrated by androgens at single-cell resolution

F. Li, X. Xing, Q. Jin, X. Wang, P. Dai, M. Han, H. Shi, Z. Zhang, X. Shao, Y. Peng, Y. Zhu, J. Xu, D. Li, Y. Chen, W. Wu, Q. Wang, C. Yu#, L. Chen#, F. Bai#,D. Gao#. Nature (2024)


xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs

R. Ding*, X. Zou*, Y. Qin, L. Gong, H. Chen, X. Ma, S. Guang, C. Yu, G. Wang#, L. Li#. Briefings in Bioinformatics 25, bbad440 (2023)


ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues

X. Ma*, S. Cheng*, R. Ding, Z. Zhao, X. Zou, S. Guang, Q. Wang, H. Jing, C. Yu, T. Ni, L. Li#. Nucleic Acids Research 51, gkac736 (2022)


A DNA-repair pathway can affect transcriptional noise to promote cell fate transitions

R. V. Desai, X. Chen, B. Martin, S. Chaturvedi, D. W. Hwang, W Li, C. Yu, S. Ding, M. Thomson, R. H. Singer, R. A. Coleman, M. M. K. Hansen, L. S. Weingerger#. Science 373, eabc6506 (2021)

Pre-PI

Therapeutic strategies targeting somatic stem cells: Chemical approaches

C. Yu, S. Ding#. Bioorganic & Medicinal Chemistry 28, 15824 (2020)


CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming

Y. Liu*, C. Yu*, T. P. Daley*, F. Wang, W. S. Cao, S. Bhate, X. Lin, C. Still, H. Liu, D. Zhao, H. Wang, X. S. Xie, S. Ding, W. H. Wong, M. Wernig, L. S. Qi# Cell Stem Cell 23, 758-771.e8 (2018)


Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine

K. Liu*, C. Yu*, M. Xie*, K. Li*, S. Ding#. Cell Chemical Biology 23, 893–916 (2016)


Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts

Y. Zhang*, N. Cao*, Y. Huang, C. I. Spencer, J. Fu, C. Yu, K. Liu, B. Nie, T. Xu, K. Li, S. Xu, B. G. Bruneau, D. Srivastava, S. Ding#. Cell Stem Cell 18, 368–381 (2016) 


Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

C. Yu, Y. Liu, T. Ma, K. Liu, S. Xu, Y. Zhang, H. Liu, M. La Russa, M. Xie, S. Ding#, L. S. Qi#.  Cell Stem Cell 16, 142–147 (2015)


Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

T. Ma*, J. Li*, Y. Xu*, C. Yu, T. Xu, H. Wang, K. Liu, N. Cao, B. Nie, S. Zhu, S. Xu, K. Li, W. Wei, Y. Wu, K. Guan, S. Ding# Nature Cell Biology 17, 1379–1387 (2015)


Chemical approaches to cell reprogramming

C. Yu, K. Liu, S. Tang, S. Ding#. Curr. Opin. Genet. Dev. 23, 28, 50–56 (2014)


Toward directed reprogramming through exogenous factors

C. Lin*, C. Yu*, S. Ding#. Curr. Opin. Genet. Dev. 23, 519–525 (2013)


Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell–derived hemato-vascular precursors

C. Yu, Y. Liu, Z. Miao, M. Yin, W. Lu, Y. Lv, M. Ding, H. Deng#.  Blood 116, 4786–4794 (2010)


Generation of homogeneous PDX1+ pancreatic progenitors from human ES cell-derived endoderm cells

J. Cai*, C. Yu*, Y. Liu, S. Chen, Y. Guo, J. Yong, W. Lu, M. Ding, H. Deng#.  J Mol Cell Biol. 2, 50–60 (2010)