Genome engineering: current advances and therapeutic opportunities in human diseases

X. Jiang*, X. Wang*, S. Shen, S. Hou^#, C. Yu^#.

Research 2025

JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination

W. Guo*, X. Zhang*, L. Li*, P. Shao*, C. Liang*, H. Zhang, K. Liu, S. Wang, Y. Peng, J. Luo, Y. Ju, A. M. De Marzo, C. Yu^#, L. Chen^#, B. Zhou^#, D. Gao^#.

Nature Genetics 2024

Engineering bacteria and their derivatives for cancer immunotherapy

Y, Tang, C. Yu^#, L. Rao^#.

BME Front 2024

Sex differences orchestrated by androgens at single-cell resolution

F. Li*, X. Xing*, Q. Jin*, X. Wang*, P. Dai*, M. Han*, H. Shi, Z. Zhang, X. Shao, Y. Peng, Y. Zhu, J. Xu, D. Li, Y. Chen, W. Wu, Q. Wang, C. Yu^#, L. Chen^#, F. Bai^#, D. Gao^#. 

Nature 2024

The cell fates of intermediate cell population in prostate development

X. Zhang, J. Wang, W. Guo, H. Zhang, B. Zhou, C. Yu, D. Gao^#.

Cell Insight 2024

ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues

X. Ma, S. Cheng, R. Ding, Z. Zhao, X. Zou, S. Guang, Q. Wang, H. Jing, C. Yu, T. Ni, L. Li^#.

Nucleic Acids Res 2023

xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs

R. Ding, X. Zou, Y. Qin, L. Gong, H. Chen, X. Ma, S. Guang, C. Yu, G. Wang, L. Li^#.

Brief. Bioinform. 2023

A DNA-repair pathway can affect transcriptional noise to promote cell fate transitions

R. V. Desai, X. Chen, B. Martin, S. Chaturvedi, D. W. Hwang, W Li, C. Yu, S. Ding, M. Thomson, R. H. Singer, R. A. Coleman, M. M. K. Hansen, L. S. Weingerger^#.

Science 2021

Therapeutic strategies targeting somatic stem cells: Chemical approaches

C. Yu, S. Ding^#.

Bioorg Med Chem 2020

CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming

Y. Liu*, C. Yu*, T. P. Daley*, F. Wang, W. S. Cao, S. Bhate, X. Lin, C. Still, H. Liu, D. Zhao, H. Wang, X. S. Xie, S. Ding, W. H. Wong, M. Wernig, L. S. Qi^#.

Cell Stem Cell 2018

Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine

K. Liu*, C. Yu*, M. Xie*, K. Li*, S. Ding^#.

Cell Chem Biol 2016

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts

Y. Zhang*, N. Cao*, Y. Huang, C. I. Spencer, J. Fu, C. Yu, K. Liu, B. Nie, T. Xu, K. Li, S. Xu, B. G. Bruneau, D. Srivastava, S. Ding^#.

Cell Stem Cell 2016

Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

C. Yu, Y. Liu, T. Ma, K. Liu, S. Xu, Y. Zhang, H. Liu, M. La Russa, M. Xie, S. Ding^#, L. S. Qi^#.

Cell Stem Cell 2015

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

T. Ma*, J. Li*, Y. Xu*, C. Yu, T. Xu, H. Wang, K. Liu, N. Cao, B. Nie, S. Zhu, S. Xu, K. Li, W. Wei, Y. Wu, K. Guan, S. Ding^#.

Nature Cell Biology 2015

Chemical approaches to cell reprogramming

C. Yu, K. Liu, S. Tang, S. Ding^#.

Curr Opin Genet Dev 2014

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell–derived hemato-vascular precursors

C. Yu, Y. Liu, Z. Miao, M. Yin, W. Lu, Y. Lv, M. Ding, H. Deng^#.

Blood 2010

Generation of homogeneous PDX1+ pancreatic progenitors from human ES cell-derived endoderm cells

J. Cai*, C. Yu*, Y. Liu, S. Chen, Y. Guo, J. Yong, W. Lu, M. Ding, H. Deng^#.

J Mol Cell Biol 2010